Written by Rich Forestano Friday, 24 January 2014 00:00
High cholesterol is bad. Elevated bad cholesterol (LDL) is even worse, and one New Hyde Park doctor is working on a study to change that.
Dr. Kenneth Hershon, an endocrinologist at North Shore Long Island Jewish Hospital in New Hyde Park, along with a team of doctors across the world, is working on medication that blocks a protein that reduces the liver’s ability to remove LDL. The medication, called a PCSK9 inhibitor, allows liver cells to take more LDL from blood because it blocks the PCSK9 protein. Hershon feels this could “change the game.”
The average LDL cholesterol should be about 70 for people at risk for heart disease. A healthy person’s LDL level is near 100.
The interest in creating better LDL medication started after a 32-year-old, Dallas, TX female aerobics instructor was found to have an LDL level of 14. This occurred because of a gene mutation that was passed down to her from her father.
According to Hershon, this sparked pharmaceutical companies like Pfizer, Sanofi and Amgen (the company that’s funding the study Hershon is working on) to fast track medication research to treat high levels of LDL. Scientists are hoping that the Texas woman's genetic makeup can help them foster a remedy.
“What they found [with the woman] was that this person was homozygous, which uprated the LDL receptors in the liver, which lets her break down the cholesterol,” he said.
Amgen is conducting The Fourier Study, which is working find a different approach to reducing LDL cholesterol. The study examines people between 40 and 85 years of age who have a history of heart attack, stroke or peripheral arterial disease.
The test will analyze 22,500 people across the globe who are considered high-risk patients. The study will chronicle patients that are on a cholesterol inhibitor. If their LDL levels are above 70, they’d be put into a Fourier trial.
“We want to know if lowering LDL with this medication will have an effect on longterm outcomes,” said Hershon. “If it does, then it’s worthwhile. If it doesn’t, then it’s cosmetic. It’s ethical because...if you’re not at goal, [in this trial] you’ll potentially stay where you are right now or lower your levels and benefit you," he said.
The study is in phase three, which is the final study phase before a company seeks approval to market a drug from the FDA. The PCSK9 being studied is called evolocumab, a monoclonal antibody developed by Amgen.
“We’ll study patients who either had a heart attack, stroke or vascular surgery,” said Hershon. “They are at the highest risk to have another event.”
High cholesterol levels are considered a risk factor of cardiovascular disease, including heart attacks and stroke, Hershon said. According to the Center for Disease Control, more than 71 million American adults have elevated LDL levels and only one-third of them have the condition under control.
Last Updated (Monday, 29 November 1999 19:00) Saturday, 08 March 2014 00:00
It’s a family affair for the Winters of Port Washington when they make pilgrimages to Bobb Howard’s General Store in New Hyde Park. “There’s something in that store for everyone,” says Tracy Winters, who has been a customer of this retro candy and toy store for eight years. Tracy goes for the Astro Pops, husband Michael gets Marshmallow Twists and Tracy’s mother, Phyllis Heller of Bellmore, can’t resist the Goldenberg Peanut Chews. Jake, Tracy’s older son, isn’t a candy lover so he gravitates to the old-time toys and nostalgia posters.
Jamie Waller of Queens says it made him feel like a kid again when he saw the wall of candy with treats from the 1990s and 1950s sitting next to each other. “Anything you can possibly want is there,” he says. For Jamie, a big treat is Circus Peanuts, peanut-shaped marshmallows. “My dad used to love them when he was a kid,” he says.
Last Updated (Monday, 29 November 1999 19:00) Friday, 07 March 2014 00:00
One fortunate New Hyde Park resident was rescued from the freezing cold on Tuesday, Feb. 25 thanks to Dr. Julia Harmon, DVM, of the New Hyde Park Animal Hospital. That night, at approximately 8 p.m., Harmon was going to her car after work when she saw Spike, a wandering bulldog near Brooklyn Avenue, one block from the vet’s office on Jericho Turnpike.
Harmon immediately brought Spike, who was not wearing a collar and did not have a microchip implanted for identification, back to the vet’s office. The temperature outside was already at 31 degrees, but felt like 20 degrees with the windchill. Luckily Spike was
brought in from the cold early; temperatures dropped down to 25 degrees that night.
Thursday, 06 March 2014 00:00
New Hyde Park Michael Castelli recently participated in the 32nd Black Belt Graduation at Charles Water Karate & Fitness, located at 122 Hillside Ave. in Williston Park. He graduated to first-degree black belt.
“Our studio teaches students how to defend themselves responsibly while instilling self-confidence, self-discipline and respect for others,” says Grandmaster Charles Water, owner and director of the school.
Students tested in October, successfully passed their exam recently and received their black belt certificates. “Who says that the youth of America are not committed? A healthy life style at the karate studio, mentally and physically is alive, well and working,” said Water.
Thursday, 06 March 2014 00:00
After missing the playoffs two straight years, the Sewanhaka Indians Boys lacrosse team will face tougher odds if it hopes to advance to postseason play in 2014.
The Indians, who start their season March 24 at Oyster Bay, will be playing out of Section 8, Nassau Conference II (Class B) this year; a bump up from their usual spot in Nassau Conference III (Class C). Typically, the schools are divided by enrollment.
“There are no gimmies in this league,” said nine-year coach Peter Burgess. “We were the last team to make this league in terms of population. They kind of drew the line below us. So we’re the smallest school in the league.”
Burgess said another obstacle for the Indians will be facing teams that they have no experience playing before.