Written by Rich Forestano Friday, 24 January 2014 00:00
High cholesterol is bad. Elevated bad cholesterol (LDL) is even worse, and one New Hyde Park doctor is working on a study to change that.
Dr. Kenneth Hershon, an endocrinologist at North Shore Long Island Jewish Hospital in New Hyde Park, along with a team of doctors across the world, is working on medication that blocks a protein that reduces the liver’s ability to remove LDL. The medication, called a PCSK9 inhibitor, allows liver cells to take more LDL from blood because it blocks the PCSK9 protein. Hershon feels this could “change the game.”
The average LDL cholesterol should be about 70 for people at risk for heart disease. A healthy person’s LDL level is near 100.
The interest in creating better LDL medication started after a 32-year-old, Dallas, TX female aerobics instructor was found to have an LDL level of 14. This occurred because of a gene mutation that was passed down to her from her father.
According to Hershon, this sparked pharmaceutical companies like Pfizer, Sanofi and Amgen (the company that’s funding the study Hershon is working on) to fast track medication research to treat high levels of LDL. Scientists are hoping that the Texas woman's genetic makeup can help them foster a remedy.
“What they found [with the woman] was that this person was homozygous, which uprated the LDL receptors in the liver, which lets her break down the cholesterol,” he said.
Amgen is conducting The Fourier Study, which is working find a different approach to reducing LDL cholesterol. The study examines people between 40 and 85 years of age who have a history of heart attack, stroke or peripheral arterial disease.
The test will analyze 22,500 people across the globe who are considered high-risk patients. The study will chronicle patients that are on a cholesterol inhibitor. If their LDL levels are above 70, they’d be put into a Fourier trial.
“We want to know if lowering LDL with this medication will have an effect on longterm outcomes,” said Hershon. “If it does, then it’s worthwhile. If it doesn’t, then it’s cosmetic. It’s ethical because...if you’re not at goal, [in this trial] you’ll potentially stay where you are right now or lower your levels and benefit you," he said.
The study is in phase three, which is the final study phase before a company seeks approval to market a drug from the FDA. The PCSK9 being studied is called evolocumab, a monoclonal antibody developed by Amgen.
“We’ll study patients who either had a heart attack, stroke or vascular surgery,” said Hershon. “They are at the highest risk to have another event.”
High cholesterol levels are considered a risk factor of cardiovascular disease, including heart attacks and stroke, Hershon said. According to the Center for Disease Control, more than 71 million American adults have elevated LDL levels and only one-third of them have the condition under control.
Last Updated (Monday, 29 November 1999 19:00) Saturday, 13 September 2014 00:00
Twenty-three-year-old Victoria Inguanta of New Hyde Park has a unique approach to her artwork. The New Hyde Park Memorial High School and Marymount College graduate takes the human body and combines figurative and abstract work using just a pencil and her canvas.
“For instance I’ll take a classical rendering of a face and bring out a modern aspect of the art using lines and space in my composition,” said Inguanta. “To me, the combining of the two is a lot of fun.”
Last Updated (Monday, 29 November 1999 19:00) Friday, 12 September 2014 00:00
The Sewanhaka Central High School District honored five educators with the Superintendent’s Teacher of the Year Award and recognized staff members with 25 years of service to the district at its Opening Day Ceremony last week, which was highlighted by presentations and student-musician performances.
Held at Sewanhaka High School, the ceremony began with the New Hyde Park Memorial High School Select Choir performing the Star Spangled Banner under the direction of choir director Robert McKinnon.
Thursday, 11 September 2014 00:00
Tara Notrica is your typical 49-year-old mother of two. Along with her husband Barry, she is kept busy by her 14-year-old son Jared and 10-year-old daughter Samantha. One more thing: she has been battling Mast Cell disease in addition to other autoimmune diseases for the past eight years. Josh York, the CEO and founder of GYMGUYZ, an in-home personal training company, has been working closely with Notrica to help her cope with her disease.
“GYMGUYZ is all about the three C’s: convenient, creative and customizable workouts,” said York. “We come to the setting of your choice from homes, offices, churches, and bring our fully loaded van, which has 365 pieces of equipment,” he continued.
Thursday, 04 September 2014 00:00
Nassau County Police Activity League Special Needs Unit hosted the recent Special Olympics New York Basketball Tournament held at Town of Oyster Bay Hicksville Athletic Center home of Nassau County PAL (NCPAL). Thirteen basketball teams, each with up to ten players, participated in the games. NCPAL-
Special Needs Unit Knights; NCPAL New Hyde Park Knights; SCO Owls; Commack Sharks; Long Island Lions: ACDS Thunderbolts, AHRC Starz and for the first time the Oakville Skywalkers, a Canadian team, competed on the court to demonstrate their skill and spirit of sportsmanship. After the games gold, silver and bronze medals and ribbons were awarded to each of the players.