Written by Rich Forestano Friday, 24 January 2014 00:00
High cholesterol is bad. Elevated bad cholesterol (LDL) is even worse, and one New Hyde Park doctor is working on a study to change that.
Dr. Kenneth Hershon, an endocrinologist at North Shore Long Island Jewish Hospital in New Hyde Park, along with a team of doctors across the world, is working on medication that blocks a protein that reduces the liver’s ability to remove LDL. The medication, called a PCSK9 inhibitor, allows liver cells to take more LDL from blood because it blocks the PCSK9 protein. Hershon feels this could “change the game.”
The average LDL cholesterol should be about 70 for people at risk for heart disease. A healthy person’s LDL level is near 100.
The interest in creating better LDL medication started after a 32-year-old, Dallas, TX female aerobics instructor was found to have an LDL level of 14. This occurred because of a gene mutation that was passed down to her from her father.
According to Hershon, this sparked pharmaceutical companies like Pfizer, Sanofi and Amgen (the company that’s funding the study Hershon is working on) to fast track medication research to treat high levels of LDL. Scientists are hoping that the Texas woman's genetic makeup can help them foster a remedy.
“What they found [with the woman] was that this person was homozygous, which uprated the LDL receptors in the liver, which lets her break down the cholesterol,” he said.
Amgen is conducting The Fourier Study, which is working find a different approach to reducing LDL cholesterol. The study examines people between 40 and 85 years of age who have a history of heart attack, stroke or peripheral arterial disease.
The test will analyze 22,500 people across the globe who are considered high-risk patients. The study will chronicle patients that are on a cholesterol inhibitor. If their LDL levels are above 70, they’d be put into a Fourier trial.
“We want to know if lowering LDL with this medication will have an effect on longterm outcomes,” said Hershon. “If it does, then it’s worthwhile. If it doesn’t, then it’s cosmetic. It’s ethical because...if you’re not at goal, [in this trial] you’ll potentially stay where you are right now or lower your levels and benefit you," he said.
The study is in phase three, which is the final study phase before a company seeks approval to market a drug from the FDA. The PCSK9 being studied is called evolocumab, a monoclonal antibody developed by Amgen.
“We’ll study patients who either had a heart attack, stroke or vascular surgery,” said Hershon. “They are at the highest risk to have another event.”
High cholesterol levels are considered a risk factor of cardiovascular disease, including heart attacks and stroke, Hershon said. According to the Center for Disease Control, more than 71 million American adults have elevated LDL levels and only one-third of them have the condition under control.
Last Updated (Monday, 29 November 1999 19:00) Tuesday, 28 October 2014 12:20
Running for his second major office in as many years, Adam Haber touched on familiar themes in a visit to Anton Media Group to discuss his candidacy for the Seventh District New York State Senate seat, where Haber is challenging the Republican incumbent, Jack Martins.
Haber entered politics in 2009, when he ran for and won, a seat on the Roslyn School Board. The district was then reeling from an embezzlement scandal that had cost it millions of dollars. Haber touted his achievements on the board, including bringing finances into line to the point where the district has seen the lowest tax increases of any district in Nassau County. Last year, Haber ran for the Democratic Party’s nomination to challenge Edward P. Mangano for the Nassau County executive’s race.
Last Updated (Monday, 29 November 1999 19:00) Thursday, 30 October 2014 00:00
After a recent security scare, the New Hyde Park-Garden City Park School District is leading a push to get public election polling moved out of school buildings. The board of education is aiming to pass its resolution at the state level to encompass all New York Schools and address what they see as a broad school security flaw.
“What’s good for our kids should be good for any child in any other public school in the entire state,” Superintendent Robert Katulak said.
Tuesday, 28 October 2014 12:34
The Sewanhaka Indians topped the Herricks Highlanders, 26-6, on Saturday, Oct. 25. The Indians (5-2) Garden City High School to close out the regular season on Saturday, Nov. 1 at 2 p.m. at 170 Rockaway Ave., Garden City.
(Photos by Stephen Takacs)
Thursday, 23 October 2014 00:00
The Sewanhaka Indians varsity football team hosted Elmont Spartans on Saturday, Oct. 18 in its final home game of the regular season.
It certainly did not go as the Indians had hoped, falling 18-8, in a mistake filled game. Head coach George Kasimatis said the Indians had their chances, but kept digging themselves into a hole with mental mistakes on both sides of the ball.
Playing from behind, senior running back Brenton Mighty was able to break free for a long touchdown run, to put the Indians on the board.