Written by Rich Forestano Friday, 24 January 2014 00:00
High cholesterol is bad. Elevated bad cholesterol (LDL) is even worse, and one New Hyde Park doctor is working on a study to change that.
Dr. Kenneth Hershon, an endocrinologist at North Shore Long Island Jewish Hospital in New Hyde Park, along with a team of doctors across the world, is working on medication that blocks a protein that reduces the liver’s ability to remove LDL. The medication, called a PCSK9 inhibitor, allows liver cells to take more LDL from blood because it blocks the PCSK9 protein. Hershon feels this could “change the game.”
The average LDL cholesterol should be about 70 for people at risk for heart disease. A healthy person’s LDL level is near 100.
The interest in creating better LDL medication started after a 32-year-old, Dallas, TX female aerobics instructor was found to have an LDL level of 14. This occurred because of a gene mutation that was passed down to her from her father.
According to Hershon, this sparked pharmaceutical companies like Pfizer, Sanofi and Amgen (the company that’s funding the study Hershon is working on) to fast track medication research to treat high levels of LDL. Scientists are hoping that the Texas woman's genetic makeup can help them foster a remedy.
“What they found [with the woman] was that this person was homozygous, which uprated the LDL receptors in the liver, which lets her break down the cholesterol,” he said.
Amgen is conducting The Fourier Study, which is working find a different approach to reducing LDL cholesterol. The study examines people between 40 and 85 years of age who have a history of heart attack, stroke or peripheral arterial disease.
The test will analyze 22,500 people across the globe who are considered high-risk patients. The study will chronicle patients that are on a cholesterol inhibitor. If their LDL levels are above 70, they’d be put into a Fourier trial.
“We want to know if lowering LDL with this medication will have an effect on longterm outcomes,” said Hershon. “If it does, then it’s worthwhile. If it doesn’t, then it’s cosmetic. It’s ethical because...if you’re not at goal, [in this trial] you’ll potentially stay where you are right now or lower your levels and benefit you," he said.
The study is in phase three, which is the final study phase before a company seeks approval to market a drug from the FDA. The PCSK9 being studied is called evolocumab, a monoclonal antibody developed by Amgen.
“We’ll study patients who either had a heart attack, stroke or vascular surgery,” said Hershon. “They are at the highest risk to have another event.”
High cholesterol levels are considered a risk factor of cardiovascular disease, including heart attacks and stroke, Hershon said. According to the Center for Disease Control, more than 71 million American adults have elevated LDL levels and only one-third of them have the condition under control.
Last Updated (Monday, 29 November 1999 19:00) Saturday, 19 April 2014 00:00
Five New Hyde Park Memorial High School students won $5,000 cash and will share a $10,000 college scholarship after winning Nassau County’s annual Comptroller’s Entrepreneurial Challenge on April 9 to conceive the best business plan to redevelop the Nassau Coliseum.
Two hundred business students from high schools across Nassau County competed for scholarships and cash awards—more than $33,000 in all.
Last Updated (Monday, 29 November 1999 19:00) Friday, 18 April 2014 00:00
Two New Hyde Park business men were arrested on Tuesday, April 8 for underreporting gross sales, Nassau County District Attorney Kathleen Rice announced.
DA Rice said Gerard Losquadro, 61 of Garden City and Charles DiMarino, 48, of East Norwich, as the former and current owner, respectively, of New Hyde Park Auto Body Works, failed to remit $149,936.65 in sales tax collected from customers to the New York State
Department of Taxation and Finance from Sept. 1, 2009 to May 31, 2013, according to the DA’s office.
Thursday, 17 April 2014 00:00
Sewanhaka’s boys lacrosse coach Peter Burgess has one rule when it comes to his goalies: make the saves that you’re supposed to make.
Luckily for Burgess, senior Jake Mellen does that and more.
“Once or twice a game he’ll make a save that no one’s supposed to make,” Burgess said. “I’ll look over to my assistant coach and say, ‘Wow, that was a special play right there’”
For three years, Mellen has been making those kind of spectacular saves for the Indians as the starting goalie. Before his senior season started, he was voted captain by his teammates and coaches.
Thursday, 17 April 2014 00:00
Coaching to some can be measured by wins and losses. But New Hyde Park’s head baseball coach Doug Robins measures his success through the success of his players, on and off the field.
Robins has coached the Gladiators varsity baseball team since 1999 and made the playoffs 10 out of those 15 seasons. His teams have finished in second place in their league twice.
Despite his teams on field success, Robins goal is to help his players succeed and receive the opportunity to play college ball.